Simulated data of urea of haemodialysis patient using one-compartment model

Nabilah S. A. Tamrin, Noorddin Ibrahim


End stage kidney disease (ESKD) is a disease where both kidneys are no longer functioning properly and patients require renal replacement therapy (RRT) such as haemodialysis to prolong their life. The numbers of modality for haemodialysis had increased, as the numbers of new patient of ESKD increased. In Malaysia, the numbers of new patient had increased three-fold for the past 10 years, from year 2002 to year 2012. In this paper, demographic data, clinical data and input and output of dialysis for the selected patients are presented. The post-dialysis urea concentrations for each patient with different weight
for one compartment model were simulated using MATLAB software. The simulated values of post-dialysis urea concentration were then compared with the clinical values of post-dialysis urea concentration for different weight. The simulated values of post-dialysis urea concentration underestimated the clinical value of post-dialysis urea concentration for patient with weight less than 70kg but overestimated to patient with weight greater than 70kg. The ratio of simulated values and clinical values of post-dialysis urea concentration were found to increase with the weight of patient

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