Clinical response of doxycycline administration to periodontal tissues of periodontitis patients with type 2 diabetes mellitus: Rapid Review

Nisrina Rufaidah HASANAH, Nunung RUSMINAH, Indra Mustika Setia PRIBADI

Abstract


ABSTRACT Diabetes mellitus is a group of physiological dysfunctions due to insulin resistance and inadequate
insulin secretion characterized by hyperglycemia. Diabetic patients have an increased risk and severity of
periodontitis. Therefore, additional periodontal treatment is required. Doxycycline is a broad-spectrum antibiotic
and has the anti collagenase ability to inhibit tissue damage. This study aims to determine the clinical response of
periodontal tissue in patients with periodontitis with type 2 diabetes mellitus to doxycycline. This rapid review was
conducted online in May-July 2021 on randomized controlled trial articles about systemic doxycycline as an
adjunctive periodontal treatment in periodontitis patients with type 2 diabetes mellitus. The search was carried out
from three electronic databases, Pubmed NCBI, Cochrane Library, and Google Scholar concerning PRISMA analysis
guidelines, using PICO strategy and the study quality assessed by SORT. Five articles were selected with good
evidence quality (level 1). Probing pocket depth (PPD), clinical attachment level (CAL), bleeding on probing (BOP),
plaque index (PI), gingival index (GI), and gingival recession were evaluated. The result showed a more significant
reduction in clinical parameters in periodontitis patients with type 2 diabetes mellitus who received additional
systemic doxycycline treatment, except gingival recession. Systemic doxycycline as an adjunctive periodontal
treatment in periodontitis patients with type 2 diabetes mellitus gave a positive clinical response, with better results
than no other doxycycline treatment group.
KEYWORDS: Doxycycline, periodontitis, diabetes mellitus


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DOI: https://doi.org/10.24815/jds.v6i2.24191

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