Plants for oral biofilms eradication: literature review

Amatul Firdaustia PRATIWI, Hening Tjaturina PRAMESTI, Faisal KUSWANDANI


ABSTRACT Oral Biofilm is a collection of microbial cell colonies related to periodontal diseases and caries. Biofilm
bacteria were more resistant to antimicrobial agents than in the planktonic phase. The rapid progression of bacterial
resistance to antimicrobial agents such as chlorhexidine has encouraged researchers to find alternative antimicrobial
agents from natural plant products with low side effects. The purpose of this review was to summarize plants that
contain bioactive compounds for biofilm eradication in terms of preventing caries and periodontal diseases. The
method was used Systematic Review without Metha Analysis. Articles to be reviewed were searched from Pubmed,
Cochrane, Science Direct, and Google Scholar databases using the PRISMA method and hand searching. The last
selected articles were analyzed using narrative analysis. There are 1,610 articles specified in the first stage and only
18 articles left in the final extraction stage. Plants that contain bioactive compounds for oral biofilm eradication
include Piper betle (betel), Psidium sp., Mangifera sp., Mentha sp., Caesalpinia sappan (secang), Baccharis dracunculifolia,
Laurus nobilis L. (dafnah), Croton nepetaefolius, Salvadora persica (miswak), Dryopteris crassirhizoma, Diospyros kaki
Thunb. (persimmon), Ginkgo biloba, Azadirachta indica (neem), Camellia sinensis, Lippia alba, Cymbopogon citratus
(lemongrass), Citrus aurantifolius, Tamarindus indica (sour), Syzygium cumini (jamblang), Emblica officinalis (malacca),
Acacia Arabica (prickly acacia), Terminalia chebula (myrobalan), Terminalia bellerica (bahera), Carica papaya, Ocimum
basilicum L. (basil), and Myrmercodia pendans. These plant bioactive compounds are belong to the group of alkaloids,
terpenoids, and polyphenols which were tested in the form of single compounds or mixtures, especially against
Streptococcus mutans. In conclusion, 26 plant species have reported containing bioactive compounds tested in the
form of single or mixed extracts to eradicate oral bacterial biofilm.
KEYWORDS: Plants, eradication, natural products, oral biofilm

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