POTENSI EKSTRAK ETANOL LABU SIAM (Sechium edule) UNTUK PERBAIKAN KERUSAKAN SEL BETA PANKREAS DAN KADAR NITROGEN OKSIDA PADA TIKUS YANG MENGALAMI DIABETES MELITUS (The Potenty of Sechium edule Ethanolic Extract to Repair Beta Pancreas Cells and Nitrogen Oxide Concentration in Streptozotocin-induced Diabetic Rat)

Betty Lukiati, Siti Imroatul Maslikah, Nugrahaningsih N

Abstract


The objectives of this research were to examine the effect of Sechium edule ethanolic extract to repair beta pancreas cells damage and to
measure nitrogen oxide (NO) concentration in streptozotocin-induced rats. Type I diabetic rats were obtained by intraperioneally injected the
rats with multiple low dose streptozotocin (MLD-STZ) for 5 days. In this research, rats were assigned into 5 treatment groups: untreated rats in
group 1 were considered as negative control, while MLD-STZ induced type 1 diabetic rats in group 2 were considered as positive control. In
another 3 groups, type 1 diabetic rats were orally treated with three doses of Sechium edule ethanolic extract (14, 28, 42 mg/kg bw) respectively
for 7 consecutive days. Repairing of beta pancreas cells were analyzed descriptively whereas concentration of NO were analyzed using one way
ANOVA and continued with LSD test (α= 0.01). The result showed that the administration of Sechium edule ethanolic extract significantly
decreased NO concentration (P<0.01) up to 67.9 µM and repaired beta pancreas cells damage. Dose of 42 mg/kg bw of Sechium edule ethanolic
extract is the effective dose for diabetic rat therapy.

Key words: Sechium edule extract, diabetic mellitus, rat, beta pancreas cells


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DOI: https://doi.org/10.21157/j.ked.hewan.v10i1.3365

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