Histopathological Finding of Burn Healing Using Ambarella Leaf (Spondias dulcis F.) and Coconut Oil on Rats (Rattus norvegicus)

Ummu Balqis, Rasmaidar R, Marwiyah M


The aims of this research was to find out the histopathological finding of II B degree burns healing on rats (Rattus norvegicus) using
ambarella leaf (Spondias dulcis F.) and coconut oil. Experimental animals used were 12 male Wistar strain rats,with the age of 2-3 months, and
100-200 grams BW. This study used 4 treatment groups, each treatment consisted of 3 rats. The II B degree burns on the backs of rats made
using electrical solder connected to the metal. Treatment was done 2 times a day for 21 days, P1 (double distilled water), P2 (ambarella leaf and
double distilled water), P3 (coconut oil), and P4 (ambarella leaf and coconut oil). Skin sampling was performed on day 7, 14, and 21 for
histopathological preparations and then stained with haematoxylin and eosin. Parameters observed such as inflammatory reactions and
distribution of collagen tissue was analyzed descriptively. The results showed that the P4 group contained fewer inflammatory cell infiltration
and more dense collagen tissue than group P1, P2, and P3. It can be concluded that group P4 (ambarella leaf and coconut oil) shows
histopathological finding burns healing better than the other treatment groups.
Key words: ambarella leaf, burns, coconut oil, healing

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DOI: https://doi.org/10.21157/j.med.vet..v8i1.3332

DOI (PDF): https://doi.org/10.21157/j.med.vet..v8i1.3332.g3124


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This work is licensed under a Creative Commons Attribution 4.0 International License.

Creative Commons License
J. Med. Vet. is licensed under a Creative Commons Attribution 4.0 International License.